Washington State Magazine

Fall 2004


Fall 2004

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In This Issue...

Features

A Little Bronze—Strategically Placed :: Although it might be better known for wine and wheat, Walla Walla is also home to one of the most prominent fine-art foundries. For a short time this fall, 32 sculptures cast at the Walla Walla Foundry will reside at 13 locations across the Pullman campus.

{ WEB EXCLUSIVE–Gallery: A little bronze—Strategically placed Photos by George Bedirian. }

Tracking Trucks :: One heavily-loaded eighteen-wheeler can cause the same highway damage as 7,000 cars. Ken Casavant and other transportation economists are trying to make sense of the effects of trucks on the state's highways.

{ WEB EXCLUSIVE–Gallery: Truck Drivin' Man Photos by Rajah Bose of the romance of trucking. }

No Hollow Promise :: Half of all new public-school teachers quit within five years, and the best and brightest are often the first to go. Worse, the attrition rate at high-needs schools is even greater. The CO-TEACH program at WSU decided to change this situation.

An Exquisite Scar :: The beauty of the channeled scablands comes from unimaginable catastrophe.

{ WEB EXCLUSIVE–Gallery: Images of Washington's Channeled Scabland Photos by Robert Hubner. }

Carlton Lewis—Still Building Bridges :: The early 1970s were tumultuous years on the WSU campus. As student body president, Carlton Lewis helped keep things from boiling over. Now he presides over Devcorp Consulting Corporation, a project management company with teeth.

Panoramas

Departments

:: SEASONS/SPORTS:Big little man Bill Tomaras

Tracking

Cover: Edison Elementary teacher Jacqui Fisher '00 with students Dillon Skedd, Alejandrina Carreño, Jorge Herrera, Kylee Martinez. Photograph by Laurence Chen.

Panoramas
Barbara Sorg hopes to use her model system to prevent the development of multiple chemical sensitivity.

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Barbara Sorg hopes to use her model system to prevent the development of multiple chemical sensitivity. Shelly Hanks

Tracing an elusive cause of panic

© Washington State University

Barbara Sorg's formaldehyde animal model has shown that exposure to the chemical increases levels of stress-hormone production.


For those who suffer from multiple chemical sensitivity, or MCS, a trip to the grocery store may be all it takes to bring on severe headaches, joint pain, muscle fatigue, dizziness, or difficulty in thinking. Barbara Sorg, professor, Veterinary and Comparative Anatomy, Pharmacology, and Physiology at Washington State University, would like to help change that.

MCS, along with panic disorder, post-traumatic stress syndrome, and other similar illnesses, is little understood. All appear to be initiated by an event such as chemical exposure, trauma, or illness. With MCS, it may be one large exposure, such as from a chemical spill, or repeated low-level exposures, such as from home pesticide spraying.

Current research suggests that in susceptible individuals, these events can cause a memory trace to be created in the brain that connects the chemical initiator and the symptoms of the disease. Once created, the memory trace can be activated not just by the original chemical, but also by other chemicals.

It is obviously difficult, if not impossible, to directly study the development of pathways in the human brain. Scientists such as Sorg usually use relevant animal models for this type of work. Sorg has spent the past eight years developing and studying a model in which exposure to formaldehyde is used to examine stress responses and conditioned fear in rats.

Increased levels of stress hormones are thought to lead to changes in the brain, some of them in areas where the brain pathways thought to be responsible for MCS occur. Conditioned fear is believed to be a relevant model for posttraumatic stress and panic disorders. It involves linking an odor or other sensory input with an unpleasant occurrence. When conditioning occurs, the sensory input alone will cause the response appropriate to the unpleasant occurrence.

Sorg's formaldehyde animal model has shown that exposure to formaldehyde makes rats more sensitive to odors in tests of conditioned fear. It also has shown that exposure to formaldehyde increases the animals' everyday or basal levels of stress-hormone production.

Currently, Sorg is using her formaldehyde research as a basis for developing a pesticide model that can be used to determine how low-level pesticide exposure may alter the ability of the brain to link pesticide exposure and the symptoms of panic. The pesticide is Lindane, a common treatment for head lice. Other scientific research has suggested that Lindane causes higher-than-normal levels of anxiety, and Sorg sees it as a good means of moving into the study of pesticides and developing a model that can be used to test other pesticides. Her initial work with Lindane indicates that there is a difference between untreated and treated animals, the latter showing a conditioned fear response lasting up to five weeks longer than that of the untreated animals.

A great deal more work will be done in order to test and refine Sorg's new model. Her goals include determining what changes in the brain are associated with the production of the conditioned fear response in treated animals. More important, for those who suffer from MCS or may develop it in the future, she will be able to use the system to test treatments that will prevent the development of the disorder or block the symptoms in those who already have it.

Categories: Health sciences | Tags: Hormones, Panic

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